Article

Characterising alphacoronavirus phenotypic traits through diversity-driven selection of spike

2024-11-22

Abstract excerpt

The capacity for viruses to spillover from one host to another is dependent on their ability to bind to and enter cells from a new host. Using a computational approach that maximises phylogenetic diversity, we selected an optimal subset of 40 alphacoronavirus spike proteins, including the two human viruses NL63 and 229E, and characterised their host-range using broad mammalian APN and ACE2 receptor libraries. Base...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb5c08ce-ab62-53dc-ac4f-91599bf14188
DOI: 10.1101/2024.11.22.624870

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterising alphacoronavirus phenotypic traits through diversity-driven selection of spikeDOI 10.1101/2024.11.22.624870Read

Sequence determinants of human-cell entry identified in ACE2-independent bat sarbecoviruses: A combined laboratory and computational network science approachSemantic proximity Read

Understanding the future risk of bat coronavirus spillover into humans – correlating sarbecovirus receptor usage, host range, and antigenicitySemantic proximity Read

Determinants of species-specific utilization of ACE2 by human and animal coronavirusesSemantic proximity Read

Determinants of species-specific utilization of ACE2 by human and animal coronavirusesSemantic proximity Read

Architects of infection: A structural overview of SARS-related coronavirus spike glycoproteinsSemantic proximity Read

Unraveling the molecular basis of host cell receptor usage in SARS-CoV-2 and other human pathogenic β-CoVsSemantic proximity Read

ACE2 binding is an ancestral and evolvable trait of sarbecovirusesSemantic proximity Read

ACE2 from <i>Pipistrellus abramus</i> bats is a receptor for HKU5 coronavirusesSemantic proximity Read

Diversity of Coronavirus ReceptorsSemantic proximity Read

Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domainsSemantic proximity Read

Detailed phylogenetic analysis of SARS-CoV-2 reveals latent capacity to bind human ACE2 receptorSemantic proximity Read

Structural Basis for Sarbecovirus Rc-o319 Spike Adaptation to <i>Rhinolophus cornutus</i> Bat ACE2 and Constraints on Switching to Human ACE2Semantic proximity Read