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Single-nucleus profiling reveals age-associated remodeling opposed by parity in the postmenopausal human ovary

2026-05-14

Abstract excerpt

The postmenopausal ovary is commonly viewed as a passive organ, and its biology and cell composition remain incompletely characterized. Here, we generated a single-nucleus atlas of the aging postmenopausal human ovary comprising 439,011 nuclei across 64 ovarian samples from 28 donors. We resolved 37 fine cell states, revealing extensive stromal, vascular, and immune heterogeneity in the postmenopausal ovary. Aging...

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Literature Corpus work
fb539a98-a525-59f4-8d8b-dc058fbeef4b
DOI
10.64898/2026.05.11.724381
Open publication

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Single-nucleus profiling reveals age-associated remodeling opposed by parity in the postmenopausal human ovaryDOI 10.64898/2026.05.11.724381
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