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Article

A comprehensive multi-omics signature of doxorubicin-induced cellular senescence in the postmenopausal human ovary.

2024-10-02

Abstract excerpt

A major aging hallmark is the accumulation of cellular senescence burden. Over time senescent cells contribute to tissue deterioration through chronic inflammation and fibrosis driven by the Senescence-Associated Secretory Phenotype (SASP). The human ovary is one of the first organs to age, and prominent age-related fibroinflammation within the ovarian microenvironment is consistent with the presence of senescent...

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Literature Corpus work
3df7a536-04b2-506c-b4d2-02db3ab3c3e7
DOI
10.1101/2024.10.02.616143
Open publication

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