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Article

WNT5a-ROR Signaling Is Essential for Alveologenesis

7 Feb 2020

Abstract excerpt

WNT5a is a mainly “non-canonical” WNT ligand whose dysregulation is observed in lung diseases such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and asthma. Germline deletion of Wnt5a disrupts embryonic lung development. However, the temporal-specific function of WNT5a remains unknown. In this study, we generated a conditional loss-of-function mouse model (Wnt5aCAG) and...

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PMID: 32046118
DOI: 10.3390/cells9020384

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