Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tacrolimus Pharmacokinetics is Associated with Gut Microbiota Diversity in Kidney Transplant Patients: Results from a Pilot Cross-Sectional Study.

Clinical pharmacology and therapeutics - 1 Jan 2024

Degraeve Alexandra L, Bindels Laure B, Haufroid Vincent, Moudio Serge, Boland Lidvine, Delongie Kevin-Alexandre, Dewulf Joseph P, Eddour Djamila Chaib, Mourad Michel, Elens Laure

Abstract excerpt

Clinical use of tacrolimus (TAC), an essential immunosuppressant following transplantation, is complexified by its high pharmacokinetic (PK) variability. The gut microbiota gains growing interest but limited investigations have evaluated its contribution to TAC PKs. Here, we explore the associations between the gut microbiota composition and TAC PKs. In this pilot cross-sectional study (Clinicaltrial.gov...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Sectional Studies
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Microbiome

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Pilot Projects

Share to RNA, Ribosomal, 16S

Share to Tacrolimus

Source

Identifiers

PMID: 37846607
DOI: 10.1002/cpt.3077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tacrolimus Pharmacokinetics is Associated with Gut Microbiota Diversity in Kidney Transplant Patients: Results from a Pilot Cross-Sectional Study.PMID 37846607Read ↗

Tacrolimus trough concentrations increase during antibiotherapy despite stable dosing in kidney transplant recipients – a retrospective analysisSemantic proximity Read ↗

Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1Semantic proximity Read ↗

Unraveling interindividual differences and functional consequences of gut microbial metabolism of immunosuppressantsSemantic proximity Read ↗

Gut Microbiome Dysbiosis is Associated with Increased Mortality following Solid Organ TransplantationSemantic proximity Read ↗

Impact of Immunosuppression on the Metagenomic Composition of the Intestinal Microbiome: a Systems Biology Approach to Post-Transplant DiabetesSemantic proximity Read ↗

Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantationSemantic proximity Read ↗

Impact of calcineurin inhibitors on gut microbiota: Focus on tacrolimus with evidence from in vivo and clinical studiesSemantic proximity Read ↗

CYP3A5 and POR gene polymorphisms as predictors of infection and graft rejection in post-liver transplant patients treated with tacrolimus - a cohort studySemantic proximity Read ↗

Gut microbiome alterations precede graft rejection in kidney transplantation patientsSemantic proximity Read ↗

Linking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in paediatric haematopoietic stem cell transplantationSemantic proximity Read ↗

Serial Blood Microbiome Profiles in Kidney Transplant Recipients: Evidence of Circulating Gut BacteriaSemantic proximity Read ↗

Pharmacogenomic Determinants of Post-Liver Transplant Diabetes Mellitus: A Systematic Review and In Silico Pharmacogenomic AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.