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Effect of the LSD1 Inhibitor RN-1 on γ-globin and Global Gene Expression during Erythroid Differentiation in Baboons ( <i>Papio anubis</i> )

2023-07-28

Abstract excerpt

Increased levels of Fetal Hemoglobin reduce the severity of symptoms of patients with sickle cell disease and decrease the risk of death. An affordable, small molecule drug that stimulates HbF expression in vivo would be ideally suited to treat the large numbers of SCD patients that exist worldwide. Our previous work showed that administration of the LSD1 (KDM1A) inhibitor RN-1 to normal baboons increased Fetal He...

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Literature Corpus work
00741cf9-b88f-52ef-abd2-4e70baeb2b81
DOI
10.1101/2023.07.28.550962
Open publication

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Effect of the LSD1 Inhibitor RN-1 on γ-globin and Global Gene Expression during Erythroid Differentiation in Baboons ( <i>Papio anubis</i> )DOI 10.1101/2023.07.28.550962
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