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Article

Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung

19 Sept 2020

Abstract excerpt

Abstract Three-dimensional lung organoids (LOs) derived from pluripotent stem cells have the potential to enhance our understanding of disease mechanisms and to enable novel therapeutic approaches in neonates with pulmonary disorders. We established a reproducible ex vivo model of lung development using transgene-free human induced pluripotent stem cells generated from fetuses and infants with Bochdalek...

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Share to Congenital Anomalies and Fetal Surgery
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PMID: 32949227
DOI: 10.1002/sctm.20-0199

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