Article

Replicative selfish genetic elements are driving rapid pathogenic adaptation of <i>Enterococcus faecium</i>

2025-03-16

Abstract excerpt

Understanding how healthcare-associated pathogens adapt in clinical environments can inform strategies to reduce their burden. Here, we investigate the hypothesis that insertion sequences (IS), prokaryotic transposable elements, are a dominant mediator of rapid genomic evolution in healthcare-associated pathogens. Among 28,207 publicly available pathogen genomes, we find high copy numbers of the replicative ISL3 f...

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Literature Corpus work: d5d425cc-8244-5d91-8aa6-88cf69faed2b
DOI: 10.1101/2025.03.16.643550

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