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Utilising Nanopore direct RNA sequencing of blood from patients with sepsis for discovery of co- and post-transcriptional disease biomarkers

2024-12-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> RNA sequencing of whole blood has been increasingly employed to find transcriptomic signatures of disease states. These studies traditionally utilize short-read sequencing of cDNA, missing important aspects of RNA expression such as differential isoform abundance and poly(A) tail length variation. <h4>Methods</h4> We used Oxford Nanopore Technologies long-read sequencing to se...

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Literature Corpus work: faf0b7b4-3c21-55b7-a72e-90ec0416bc64
DOI: 10.1101/2024.12.13.24318230

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