Article

A genetic screening identifies a component of the SWI/SNF complex, Arid1b as a senescence regulator

2013-01-01

Abstract excerpt

Senescence is an important tumour suppressor mechanism, which prevents the proliferation of stressed or damaged cells. The use of RNA interference to identify genes with a role in senescence is an important tool in the discovery of novel cancer genes. In this work, a protocol was established for conducting bypass of senescence screenings, using shRNA libraries together with next-generation sequencing. Using this a...

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Literature Corpus work: fadd35c0-14e1-5212-ad5d-c395aa928a2c
DOI: 10.25560/18927

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