Back to search

Article

Context-Specific Innate Immune Evasion via VDAC1 Gate-Jamming in Microsatellite-Stable Colorectal Cancer

2026-02-26

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint inhibitors (ICIs) have transformed oncology for microsatellite instability-high (MSI-H) colorectal cancer, yet 85–95% of colorectal cancer patients carry microsatellite-stable (MSS) tumors and derive no benefit from current ICI regimens. We propose that VDAC1-mediated mitochondrial DNA (mtDNA) gate-jamming — suppression of VDAC1 oligomerization by HK-II docking, Bcl-xL...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fab8b6c8-541f-54f6-9d5a-58f27ef74e27
DOI
10.21203/rs.3.rs-8935902/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Context-Specific Innate Immune Evasion via VDAC1 Gate-Jamming in Microsatellite-Stable Colorectal CancerDOI 10.21203/rs.3.rs-8935902/v1
Immune checkpoint inhibitors in POLE/POLD1 proofreading-deficient CRC: from molecular basis to clinical practice and future directions.Semantic proximity
Mechanisms of genomic instability dictate cytosolic DNA composition and dendritic cell mediated anti-tumor immunitySemantic proximity
Microbial induction of MHC-II expression in colon cancer cells overcomes immunotherapy resistance and limits metastasisSemantic proximity
Reovirus sensitizes microsatellite stable colorectal cancer to anti-PD-1 treatment via cross-talk in innate and adaptive immune systemsSemantic proximity
Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancersSemantic proximity
Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1.Semantic proximity
Targeting MDA5 enhances tumor immunity through immunogenic cell death and augments the efficacy of immune checkpoint blockadeSemantic proximity
ACB1801 enhances tumor immunogenicity by targeting glycolysis/ferroptosis vulnerability and activating STAT1-signaling to overcome anti-PD-1 resistance in MSS colorectal cancerSemantic proximity
Dysfunctional tumor-infiltrating Vδ1 + T lymphocytes in microsatellite-stable colorectal cancerSemantic proximity
An in situ immunogenicity-amplifying payload delivery system for immunotherapy of Kirsten rat sarcoma viral oncogene homolog-mutant cancer.Semantic proximity
Can TP53, TMB and TME Expand the Immunotherapy Benefit in Metastatic Colorectal Cancer?Semantic proximity
Beyond proofreading: POLD1 mutations as dynamic orchestrators of genomic instability and immune evasion in cancerSemantic proximity
Select a neighboring publication to make it the new centre.