Article

Contrasting PD1 blockade responses and immunogenomic contexts in MSI high rectosigmoid adenocarcinomas

2026-09-01

Abstract excerpt

<title>Abstract</title> <p>Mismatch-repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC) is generally sensitive to PD-1 blockade, yet not all patients derive durable benefit. We report two contemporaneously treated patients with bulky, locally advanced MSI-H rectosigmoid adenocarcinoma who received tislelizumab monotherapy at the same centre but had markedly divergent outcomes. Pa...

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Literature Corpus work: e2c2da88-756e-5496-a0c9-f0ae4eaf5e91
DOI: 10.21203/rs.3.rs-10729495/v1

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