Article

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury

2025-09-17

Abstract excerpt

Vascular normalization [stabilization of aberrant angiogenesis and restoration of blood-brain barrier (BBB)] is critical for reducing long-term secondary sequelae after ischemic stroke. How immune and developmental signaling pathways coordinate these processes is poorly understood. Here we identify a unique brain endothelial cell (BEC) type one interferon (IFN1) signature in human and mouse ischemic stroke tissue....

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Identifiers and source

Literature Corpus work: 94c380da-39d9-5cce-aaae-60fb77eae060
DOI: 10.1101/2025.09.09.675258

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