Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome

5 Oct 2022

Abstract excerpt

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic, aggressive cancer that frequently progresses and spreads by metastasis to the liver 1 . Cancer-associated fibroblasts, the extracellular matrix and type I collagen (Col I) support 2,3 or restrain the progression of PDAC and may impede blood supply and nutrient availability 4 . The dichotomous role of the stroma in PDAC, and the mechanisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caveolin-1 and cellular processes
Share to Cell Adhesion Molecules Research
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36198801
DOI: 10.1038/s41586-022-05169-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcomePMID 36198801Read ↗

Stromal biology of pancreatic cancerSemantic proximity Read ↗

NetrinG1 <sup>+</sup> cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stressSemantic proximity Read ↗

Collagen type I promotes pancreatic tumor growth and limits immune cell infiltrationSemantic proximity Read ↗

Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesisSemantic proximity Read ↗

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cellsSemantic proximity Read ↗

Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targetsSemantic proximity Read ↗

DDR1-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS DRIVE PANCREATIC CANCER METASTASISSemantic proximity Read ↗

A targetable opioid/cancer associated fibroblast axis drives extracellular matrix remodeling and tumor aggressiveness in pancreatic cancerSemantic proximity Read ↗

Nutrient availability-driven changes in extracellular matrix biochemical and mechanical properties regulate pancreatic cancer cell biologySemantic proximity Read ↗

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and functionSemantic proximity Read ↗

Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM CompositionSemantic proximity Read ↗

A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.