Article

EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition

2021-10-07

Abstract excerpt

The conserved 3’-5’ exoribonuclease EXOSC10/Rrp6 is required for gametogenesis, brain development, erythropoiesis and blood cell enhancer function. The human ortholog is essential for mitosis in cultured cancer cells. Little is known, however, about the role of Exosc10 during embryo development and organogenesis. We generated an Exosc10 knockout model and find that Exosc10 −/− mice show an embryonic lethal phen...

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Literature Corpus work: fa71a046-071b-5189-8e33-8ea6a6027526
DOI: 10.1101/2021.10.06.463350

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