Article

Computational Pipeline for the Design and In Silico Evaluation of Novel Hydroxamate-Macrocyclic Hybrid Chelators for Zirconium-89 and Actinium-225 Radiopharmaceuticals

2025-08-21

Abstract excerpt

<title>Abstract</title> The advancement of radiopharmaceutical agents for theranostic applications is constrained by the limited availability of high-performance chelators capable of forming thermodynamically stable and kinetically inert complexes with medically relevant radiometals. This is particularly challenging for positron emitters like Zirconium-89 (89Zr) for immuno-PET imaging and alpha emitters such a...

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Literature Corpus work: fa53f1f6-9657-5979-abef-231bce456b72
DOI: 10.21203/rs.3.rs-7407680/v1

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