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Advances in the Chemical Biology of Desferrioxamine B

28 Nov 2017

Abstract excerpt

Desferrioxamine B (DFOB) was discovered in the late 1950s as a hydroxamic acid metabolite of the soil bacterium Streptomyces pilosus. The exquisite affinity of DFOB for Fe(III) identified its potential for removing excess iron from patients with transfusion-dependent hemoglobin disorders. Many studies have used semisynthetic chemistry to produce DFOB adducts with new properties and broad-ranging functions. More...

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PMID: 29182270
DOI: 10.1021/acschembio.7b00851

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