Article

Small molecule-induced ERBB4 activation to treat heart failure

2024-04-08

Abstract excerpt

<title>Abstract</title> <p>Heart failure is a common and deadly disease, requiring new therapeutic approaches. The neuregulin-1 (NRG1)/erythroblastic leukemia viral oncogene homolog 4 (ERBB4) pathway is an interesting target because of its cardioprotective effects. The therapeutic use of recombinant NRG1 has been difficult, because it requires intravenous administration and is non-selective for the ERBB4 receptor...

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Literature Corpus work: 620ab4d1-a7a8-572f-9c5a-f30be0c93f99
DOI: 10.21203/rs.3.rs-4175488/v1

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