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Vector-borne Trypanosoma brucei parasites develop in artificial human skin and persist as skin tissue forms

23 Nov 2023

Abstract excerpt

Transmission of Trypanosoma brucei by tsetse flies involves the deposition of the cell cycle-arrested metacyclic life cycle stage into mammalian skin at the site of the fly's bite. We introduce an advanced human skin equivalent and use tsetse flies to naturally infect the skin with trypanosomes. We detail the chronological order of the parasites' development in the skin by single-cell RNA sequencing and find a...

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PMID: 37996412
DOI: 10.1038/s41467-023-43437-2

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