Article

Vector-borne <i>Trypanosoma brucei</i> parasites develop in artificial human skin and persist as skin tissue forms

2021-05-13

Abstract excerpt

<h4>Summary</h4> Transmission of Trypanosoma brucei by tsetse flies involves the deposition of the cell cycle-arrested metacyclic life cycle stage into mammalian skin at the site of the fly’s bite. In the skin, the metacyclic parasites reactivate and differentiate into proliferative trypanosomes before colonizing the host’s blood and tissues. We generated an advanced human skin equivalent and used tsetse flies t...

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Literature Corpus work: ede31c0e-950e-5244-826e-70df1211c0a7
DOI: 10.1101/2021.05.13.443986

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