Article

Orthogonal analysis of mitochondrial function in Parkinson’s disease patients

2023-07-12

Abstract excerpt

The etiopathology of Parkinson’s disease has been associated with mitochondrial defects at genetic, laboratory, epidemiological, and clinical level. These converging lines of evidence suggest that mitochondrial defects are systemic and causative factors in the pathophysiology of PD, rather than being mere correlates. Understanding mitochondrial biology in PD at granular level is therefore crucial from both basic s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa260d8a-d2a7-5de0-ad65-e12424489848
DOI: 10.1101/2023.07.11.548533

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Orthogonal analysis of mitochondrial function in Parkinson’s disease patientsDOI 10.1101/2023.07.11.548533Read

Orthogonal analysis of mitochondrial function in Parkinson’s disease patientsSemantic proximity Read

Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons.Semantic proximity Read

Mitochondrial Dysfunction in Parkinson’s DiseaseSemantic proximity Read

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neuronsSemantic proximity Read

Mitochondrial fitness influences neuronal excitability of dopaminergic neurons from patients with idiopathic form of Parkinson’s diseaseSemantic proximity Read

Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships.Semantic proximity Read

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and FunctionalitySemantic proximity Read

Mitochondrial alterations by PARKIN in dopaminergic neurons using PARK2 patient-specific and PARK2 knockout isogenic iPSC lines.Semantic proximity Read

Altered Mitochondrial Bioenergetics and Calcium Kinetics in Young‐Onset PLA2G6 Parkinson's Disease iPSCsSemantic proximity Read

Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: altered mitochondrial and energy metabolismSemantic proximity Read

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived NeuronsSemantic proximity Read

Oxidative switch drives mitophagy defects in dopaminergic <i>parkin</i> mutant patient neuronsSemantic proximity Read