Article

Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: altered mitochondrial and energy metabolism

2020-07-10

Abstract excerpt

PARK2 (parkin) mutations cause early onset of autosomal recessively inherited Parkinson’s disease (PD). Parkin is an ubiquitin E3 ligase and has been reported to participate in several cellular functions, including mitochondrial homeostasis. However, the specific metabolomic changes caused by parkin depletion remain largely unknown. Human induced pluripotent stem cells (iPSCs) with PARK2 knockout (KO) provide a v...

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Literature Corpus work: 07f1fe64-6cb7-5eb2-8c27-767e5bc18eae
DOI: 10.1101/2020.07.10.151902

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