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Article

Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships.

Experimental neurology - 1 Dec 2009

Keeney Paula M, Dunham Lisa D, Quigley Caitlin K, Morton Stephanie L, Bergquist Kristen E, Bennett James P

Abstract excerpt

Sporadic Parkinson's disease (sPD) is a nervous system-wide disease that presents with a bradykinetic movement disorder and frequently progresses to include depression and cognitive impairment. Cybrid models of sPD are based on expression of sPD platelet mitochondrial DNA (mtDNA) in neural cells and demonstrate some similarities to sPD brains. In sPD and CTL cybrids we characterized aspects of mitochondrial...

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Identifiers

PMID: 19815014
DOI: 10.1016/j.expneurol.2009.09.025
PMCID: PMC2783275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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