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RORα inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity

6 Jan 2024

Abstract excerpt

BACKGROUND: Glycolysis is critical for harvesting abundant energy to maintain the tumor microenvironment in malignant tumors. Retinoic acid-related orphan receptor α (RORα) has been identified as a circadian gene. However, the association of glycolysis with RORα in regulating gastric cancer (GC) proliferation remains poorly understood. METHODS: Bioinformatic analysis and retrospective study were utilized to...

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PMID: 38184549
DOI: 10.1186/s12935-023-03201-4

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