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From 2D Monolayer to 3D Spheroid: Matrigel’s Spatial and Chemical Cues Remodel the Calu-3 Proteome

2025-09-02

Abstract excerpt

<h4>ABSTRACT</h4> The limited physiological relevance of conventional 2D cell cultures hampers translational research. While 3D cultures offer a superior alternative, their reliance on undefined scaffolds like Matrigel makes it difficult to distinguish cellular responses to physical architecture from those to biochemical cues. This study provides a high-resolution, label-free quantitative comparison of the Calu-3...

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Literature Corpus work
f9e8e473-8b96-50eb-a8db-02d3d84babaf
DOI
10.1101/2025.08.28.672967
Open publication

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