Article

Comparative Microsomal Proteomics of A Model Lung Cancer Cell Line NCI-H23 Reveals Distinct Differences Between Molecular Profiles of 3D and 2D Cultured Cells

2020-09-21

Abstract excerpt

<h4>Background: </h4> Lung cancer is the leading cause of cancer-related deaths in the USA and worldwide. Yet, about 95% of new drug candidates validated in preclinical phase eventually fail in clinical trials. Such a high attrition rate is attributed mostly to the inability of conventional two-dimensionally (2D) cultured cancer cells to mimic native three-dimensional (3D) growth of malignant cells in human tumors...

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Literature Corpus work: d0bead8c-8806-5da7-980a-b5040fe4cc67
DOI: 10.21203/rs.3.rs-72194/v1

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