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Article

Three-Dimensional Cell Culture Conditions Affect the Proteome of Cancer-Associated Fibroblasts

10 Jul 2018

Abstract excerpt

In vitro cell culture systems are an invaluable tool for cell biological research to study molecular pathways and to characterize processes critical in human pathophysiology. However, the experimental conditions in two-dimensional (2D) cell cultures often differ substantially from the in vivo situation, which continuously raises concerns about the reliability and conferrability of the obtained results....

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PMID: 29989826
DOI: 10.1021/acs.jproteome.8b00237

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