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Article

Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo

5 Nov 2014

Abstract excerpt

Mitochondrial dysfunction has been reported in both familial and sporadic Parkinson's disease (PD). However, effective therapy targeting this pathway is currently inadequate. Recent studies suggest that manipulating the processes of mitochondrial fission and fusion has considerable potential for treating human diseases. To determine the therapeutic impact of targeting these pathways on PD, we used two...

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PMID: 25370169
DOI: 10.1038/ncomms6244

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