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Article

Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction.

Journal of neurochemistry - 1 Jun 2012

Wang Xinglong, Petrie Timothy G, Liu Yingchao, Liu Jun, Fujioka Hisashi, Zhu Xiongwei

Abstract excerpt

Mitochondrial dysfunction represents a critical event during the pathogenesis of Parkinson's disease (PD) and expanding evidences demonstrate that an altered balance in mitochondrial fission/fusion is likely an important mechanism leading to mitochondrial and neuronal dysfunction/degeneration. In this study, we investigated whether DJ-1 is involved in the regulation of mitochondrial dynamics and function in...

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Identifiers

PMID: 22428580
DOI: 10.1111/j.1471-4159.2012.07734.x
PMCID: PMC3740560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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