Article

Evolution of drug resistance drives progressive destabilizations in functionally conserved molecular dynamics of the flap region of the HIV-1 protease

2022-11-24

Abstract excerpt

The HIV-1 protease is one of several common key targets of combination drug therapies for human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS). During the progression of the disease, some individual patients acquire -drug resistance due to mutational hotspots on the viral proteins targeted by combination drug therapies. It has recently been discovered that drug-resistant mutatio...

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Literature Corpus work: f99c56c5-a230-52da-9dbd-fba72633a33d
DOI: 10.1101/2022.11.22.517502

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