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Article

A synergy of activity, stability, and inhibitor-interaction of HIV-1 protease mutants evolved under drug-pressure.

Protein science : a publication of the Protein Society - 1 Mar 2021

Khan Shahid N, Persons John D, Guerrero Michel, Ilina Tatiana V, Oda Masayuki, Ishima Rieko

Abstract excerpt

A clinically-relevant, drug-resistant mutant of HIV-1 protease (PR), termed Flap+(I54V) and containing L10I, G48V, I54V and V82A mutations, is known to produce significant changes in the entropy and enthalpy balance of drug-PR interactions, compared to wild-type PR. A similar mutant, Flap+(I54A) , which evolves from Flap+(I54V) and contains the single change at residue 54 relative to Flap+(I54V) , does not. Yet,...

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Identifiers

PMID: 33314454
DOI: 10.1002/pro.4013
PMCID: PMC7888579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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