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Article

Studies on adaptability of binding residues and flap region of TMC-114 resistance HIV-1 protease mutants.

Journal of biomolecular structure & dynamics - 1 Aug 2011

Purohit Rituraj, Rajendran Vidya, Sethumadhavan Rao

Abstract excerpt

Drug resistant mutations have severely restricted the success of HIV therapy. These mutations frequently involve the aspartic protease encoded by the virus. Knowledge of the molecular mechanisms underlying the conformational changes of HIV-1 protease mutants may be useful in developing more effective and longer lasting treatment regimes. The flap regions of the protease are the target of a particular type of...

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Source

Identifiers

PMID: 21696230
DOI: 10.1080/07391102.2011.10507379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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