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Article

Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease

12 Jun 2014

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Under the selective pressure of therapy, HIV-1 protease mutants resistant to inhibitors evolve to confer drug resistance. Such mutations can impact both the dynamics and structures of the bound and unbound forms of the enzyme. Flap+ is a multidrug-resistant variant of HIV-1 protease with a combination of primary and secondary resistance mutations (L10I, G48V,...

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PMID: 25136270
DOI: 10.1021/ct4010454

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