Article

Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum

2024-03-20

Abstract excerpt

Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 687,005 controls. We identified 21 genetic risk loci for infertility ( P ≤5E-08), of which 12 have not been reported for any reproductive condition. We found positive genetic cor...

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Literature Corpus work: 76ed0578-11d2-5cc4-b298-009e57fdb3bd
DOI: 10.1101/2024.03.19.24304530

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