Article
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
Nature human behaviour - 1 Dec 2021
Mills Melinda C, Tropf Felix C, Brazel David M, van Zuydam Natalie, Vaez Ahmad, Pers Tune H, Snieder Harold, Perry John R B, Ong Ken K, den Hoed Marcel, Barban Nicola, Day Felix R
Abstract excerpt
Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5-6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4-14%] for women born in...
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