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Mitochondria-mediated apoptosis in mammals

29 Jul 2014

Abstract excerpt

The mitochondria-mediated caspase activation pathway is a major apoptotic pathway characterized by mitochondrial outer membrane permeabilization (MOMP) and subsequent release of cytochrome c into the cytoplasm to activate caspases. MOMP is regulated by the Bcl-2 family of proteins. This pathway plays important roles not only in normal development, maintenance of tissue homeostasis and the regulation of immune...

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PMID: 25073422
DOI: 10.1007/s13238-014-0089-1

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