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Article

Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x(L) in a strictly caspase-3-dependent manner in human carcinoma cells.

Oncogene - 3 Jun 2004

Hasenjäger Anne, Gillissen Bernhard, Müller Antje, Normand Guillaume, Hemmati Philipp G, Schuler Martin, Dörken Bernd, Daniel Peter T

Abstract excerpt

The mitochondrial apoptosis pathway mediates cell death through the release of various pro-apoptotic factors including cytochrome c and Smac, the second mitochondrial activator of caspases, into the cytosol. Smac was shown previously to inhibit IAP proteins and to facilitate initiation of the caspase cascade upon cytochrome c release. To investigate Smac function during apoptosis and to explore Smac as an...

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PMID: 15064710
DOI: 10.1038/sj.onc.1207594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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