Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.

doi:10.1038/ncb3596

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Article

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.

Nature cell biology - 1 Sept 2017

Giampazolias Evangelos, Zunino Barbara, Dhayade Sandeep, Bock Florian, Cloix Catherine, Cao Kai, Roca Alba, Lopez Jonathan, Ichim Gabriel, Proïcs Emma, Rubio-Patiño Camila, Fort Loic, Yatim Nader, Woodham Emma, Orozco Susana, Taraborrelli Lucia, Peltzer Nieves, Lecis Daniele, Machesky Laura, Walczak Henning, Albert Matthew L, Milling Simon, Oberst Andrew, Ricci Jean-Ehrland, Ryan Kevin M, Blyth Karen, Tait Stephen W G

Abstract excerpt

Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity. Caspase activity can also have a variety of unwanted consequences that include DNA damage. We therefore investigated whether MOMP-induced caspase-independent cell death (CICD) might be a better way to kill...

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PMID: 28846096
DOI: 10.1038/ncb3596
PMCID: PMC5624512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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