Article

High expression of formin-2 can promote ovarian cancer chemoresistance via immunosuppressive macrophages

2025-08-07

Abstract excerpt

<title>Abstract</title> <p> Ovarian cancer (OC) remains a major threat to women’s health, with chemoresistance driven by the immunosuppressive tumor microenvironment. Formin-2 (FMN2), a cytoskeletal regulator, was investigated for its role in OC chemoresistance and macrophage polarization. Bioinformatics analysis identified high FMN2 expression in chemotherapy-resistant OC cell lines, validated experimentally. S...

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Literature Corpus work: 632ede1e-fd9f-5522-bc06-087026656eeb
DOI: 10.21203/rs.3.rs-7209240/v1

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