Article

Chemotherapy Induces an IL1β-dependent Neutrophil Recruitment that Promotes Chemoresistance in Metastatic Ovarian Cancer

2025-09-21

Abstract excerpt

High-grade serous carcinoma (HGSC) of the ovary acquires chemoresistance through diverse cancer cell-intrinsic and-extrinsic mechanisms, culminating in treatment-refractory intraperitoneal metastasis. How chemotherapy-induced remodeling of the tumor microenvironment modulates drug sensitivity remains unclear. In this study, we demonstrate that chemotherapy induced IL1β-dependent neutrophil accumulation in tumors,...

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Literature Corpus work: 438f7b1d-4c91-557e-8f11-2cfe70932516
DOI: 10.1101/2025.09.21.677600

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