Article

deCLUTTER <sup>2+</sup> pipeline to analyze calcium traces in a novel stem cell model for ventral midbrain patterned astrocytes

2022-11-09

Abstract excerpt

Astrocytes are the most populous cell type of the human central nervous system and are essential for physiological brain function. Increasing evidence suggests multiple roles for astrocytes in Parkinson’s disease (PD), nudging a shift in the research focus, which historically pivoted around the ventral midbrain dopaminergic neurons (vmDANs). Studying human astrocytes and other cell types in vivo remains technicall...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f9729723-d53c-558d-a7e1-a41c0c247bd8
DOI: 10.1101/2022.11.08.515628

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

deCLUTTER <sup>2+</sup> pipeline to analyze calcium traces in a novel stem cell model for ventral midbrain patterned astrocytesDOI 10.1101/2022.11.08.515628Read

Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCsSemantic proximity Read

A novel approach to increase glial cell populations in brain microphysiological systemsSemantic proximity Read

Functional identification of cell phenotypes differentiating from mice retinal neurospheres using single cell calcium imaging.Semantic proximity Read

In vitro human stem cell derived cultures to monitor calcium signaling in neuronal development and functionSemantic proximity Read

Single-Cell Transcriptomics Reveals the Molecular Logic Underlying Ca <sup>2+</sup> Signaling Diversity in Human and Mouse BrainSemantic proximity Read

Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses NeurogenesisSemantic proximity Read

Norepinephrine regulates Ca <sup>2+</sup> signals and fate of oligodendrocyte progenitor cells in the cortexSemantic proximity Read

Rapid specification of human pluripotent stem cells to functional astrocytesSemantic proximity Read

IPSC-derived midbrain astrocytes from Parkinson’s disease patients carrying pathogenic <i>SNCA</i> mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium releaseSemantic proximity Read

Aberrant calcium signaling in astrocytes inhibits neuronal excitability in a human Down syndrome stem cell modelSemantic proximity Read

An open-source pipeline for calcium imaging and all-optical physiology in human stem cell-derived neuronsSemantic proximity Read

CaPTure: Calcium PeakToolbox for analysis of <i>in vitro</i> calcium imaging dataSemantic proximity Read