Article

Characterization and optimization of variability in a human colonic epithelium culture model

2023-09-22

Abstract excerpt

<h4>Summary</h4> Animal models have historically been poor preclinical predictors of gastrointestinal (GI) directed therapeutic efficacy and drug-induced GI toxicity. Human stem and primary cell-derived culture systems are a major focus of efforts to create biologically relevant models that enhance preclinical predictive value of intestinal efficacy and toxicity. The inherent variability in stem-cell-based comple...

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Literature Corpus work: f9700e08-0265-5757-bd82-1ab1dada7f31
DOI: 10.1101/2023.09.22.559007

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