Article

Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer

2025-05-28

Abstract excerpt

The extracellular matrix (ECM) in the tumor microenvironment plays an essential role in cancer progression. High expression of Jagged1 correlates with poor patient survival and promotes in vivo tumor growth and invasion in triple-negative breast cancer (TNBC). Using transcriptomics, proteomics, and imaging of cancer cell/fibroblast co-cultures, both in vitro and in vivo , we demonstrate that Jagged1-mediated cr...

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Literature Corpus work: f964e4d6-2b08-5ecf-bbcb-d3d18bcc128b
DOI: 10.1101/2025.05.23.655829

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