Article

MK801 Regulates the Expression of Key Osteoarthritis Factors in Osteoarthritis Synovial Fibroblasts Through Complement C5

2020-12-29

Abstract excerpt

<h4>Background: </h4> Osteoarthritis is currently one of the most common chronic diseases. As life expectancy increases, its prevalence and incidence are expected to rise. At present, more and more evidences prove the correlation between the complement system and OA. This study aims to investigate complement C5's influence on the effect of MK801 on osteoarthritis synovial fibroblasts (OA-SFs). <h4>Methods: </h4>:...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea8f31e7-196a-57a3-b135-b728de558886
DOI: 10.21203/rs.3.rs-135712/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MK801 Regulates the Expression of Key Osteoarthritis Factors in Osteoarthritis Synovial Fibroblasts Through Complement C5DOI 10.21203/rs.3.rs-135712/v1Read

PSMB9 Exacerbates Chondrocyte Injury in Osteoarthritis via Activation of the NF-κB PathwaySemantic proximity Read

In vitro experiments confirm that CX3CR1 can be used as a biomarker for the diagnosis and treatment of osteoarthritisSemantic proximity Read

Proteomic analysis of knee cartilage reveals potential signaling pathways in pathological mechanism of Kashin-Beck disease compared with osteoarthritisSemantic proximity Read

Beyond the Norm: The emerging interplay of complement system and extracellular matrix in the tumor microenvironmentSemantic proximity Read

Cyanidin ameliorates the progression of osteoarthritis via the Sirt6/NF-κB axis in vitro and in vivoSemantic proximity Read

Yiqi Yangxue Qufeng Mixture alleviates knee osteoarthritis by modulating mitochondrialoxidative stress and suppressing ferroptosis via the PRKCA-MAPK/ERK axisSemantic proximity Read

Quantitative Proteomic Analysis of Bi Zhong Xiao Decoction Against Collagen-induced Arthritis Rats in the Early and Late StagesSemantic proximity Read

ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.Semantic proximity Read

Role of macrophage polarization in osteoarthritis (Review)Semantic proximity Read

C1, MBL–MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammationSemantic proximity Read

Macrophages drive the inflammatory phase in experimental osteoarthritisSemantic proximity Read

C1QA is an invariant biomarker for tissue macrophagesSemantic proximity Read