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Article

An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016

Becker Philipp W, Sacilotto Natalia, Nornes Svanhild, Neal Alice, Thomas Max O, Liu Ke, Preece Chris, Ratnayaka Indrika, Davies Benjamin, Bou-Gharios George, De Val Sarah

Abstract excerpt

OBJECTIVE: The vascular endothelial growth factor (VEGF) receptor Flk1 is essential for vascular development, but the signaling and transcriptional pathways by which its expression is regulated in endothelial cells remain unclear. Although previous studies have identified 2 Flk1 regulatory enhancers, these are dispensable for Flk1 expression, indicating that additional enhancers contribute to Flk1 regulation in...

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Source

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Identifiers

PMID: 27079877
DOI: 10.1161/ATVBAHA.116.307517
PMCID: PMC4894770

Genes

RBPJ

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