Article
Structural and biophysical analysis of sero-specific immune responses using epitope grafted Dengue ED3 mutants.
Biochimica et biophysica acta - 1 Oct 2015
Kulkarni Manjiri R, Islam Monirul M, Numoto Nobutaka, Elahi Montasir, Mahib Mamunur R, Ito Nobutoshi, Kuroda Yutaka
Abstract excerpt
Dengue fever is a re-emerging tropical disease and its severe form is caused by cross-reactivity between its four serotypes (DEN1, DEN2, DEN3 and DEN4). The third domain of the viral envelope protein (ED3) contains the two major putative epitopes and is a highly suitable model protein for examining the molecular determinants of a virus' sero-specificity. Here we examine d the sero-specificity and cross-reactivity...
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