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Article

An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc mutation-driven intestinal tumorigenesis.

Science immunology - 3 Jun 2022

Jou Eric, Rodriguez-Rodriguez Noe, Ferreira Ana-Carolina F, Jolin Helen E, Clark Paula A, Sawmynaden Kovilen, Ko Michelle, Murphy Jane E, Mannion Jonathan, Ward Christopher, Matthews David J, Buczacki Simon J A, McKenzie Andrew N J

Abstract excerpt

Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) defend the host against intestinal helminth infection and are associated with inappropriate allergic reactions. IL-33-activated ILC2s were previously found to augment protective tissue-specific pancreatic cancer immunity. Here, we showed that intestinal IL-25-activated ILC2s created an innate cancer-permissive microenvironment. Colorectal cancer...

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Share to Adenomatous Polyposis Coli Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35658010
DOI: 10.1126/sciimmunol.abn0175
PMCID: PMC7612821

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