Article

HAT1 drives a gene-metabolite circuit that links nutrient metabolism to histone production

2019-06-10

Abstract excerpt

<h4>Summary</h4> The energetic costs of duplicating chromatin along with DNA replication are large and therefore likely depend on nutrient sensing checkpoints and metabolic inputs. By studying chromatin modifiers regulated by epithelial growth factor, we identify histone acetyltransferase 1 (HAT1) as an induced gene that enhances cell proliferation by coordinating histone production with glucose metabolism. In ad...

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Literature Corpus work: 426cd2dc-977a-5108-8355-4210189f4a9f
DOI: 10.1101/664615

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