Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights into the emerging immune checkpoint NR2F6 in cancer immunity

26 Dec 2024

Abstract excerpt

NR2F6 has emerged as a key player in immune regulation, especially in cancer immunity. It has been reported that NR2F6 could suppress the antitumor immune response and has therefore been suggested as a possible target in cancer immunotherapy. In this review, we start by describing the complex structure of the NR2F6 gene and its multifaceted biological functions. Then, we examine its expression in distinct immune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39722227
DOI: 10.1093/jleuko/qiae260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights into the emerging immune checkpoint NR2F6 in cancer immunityPMID 39722227Read ↗

Melanoma-intrinsic NR2F6 activity regulates anti-tumor immunitySemantic proximity Read ↗

Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapySemantic proximity Read ↗

Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockadeSemantic proximity Read ↗

Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6Semantic proximity Read ↗

NR2F6 promotes the malignant progression of neuroblastoma as an indicator of poor prognosisSemantic proximity Read ↗

Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapySemantic proximity Read ↗

Reversible control of T cell exhaustion by NR4A transcription factors revealed through targeted protein degradationSemantic proximity Read ↗

Nuclear orphan receptor NR2F6 confers cisplatin resistance in epithelial ovarian cancer cells by activating the Notch3 signaling pathwaySemantic proximity Read ↗

ULBP6/RAET1L is an additional human NKG2D ligandSemantic proximity Read ↗

AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunitySemantic proximity Read ↗

NRIR promotes immune escape in hepatocellular cancer by regulating IFNγ-induced PD-L1 expressionSemantic proximity Read ↗

KDM6A regulates immune response genes in multiple myelomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.