Article

Small molecule inhibitors of the SARS-CoV Nsp15 endoribonuclease

2010-09-01

Abstract excerpt

Abstract: The severe acute respiratory syndrome (SARS) virus encodes several unusual RNA processing enzymes, including Nsp15, an endoribonuclease that preferentially cleaves 3’ of uridylates through a ribonuclease A (RNase A)-like mechanism. Crystal structures of Nsp15 confirmed that the Nsp15 active site is structurally similar to that of RNase A. These similarities and our molecular docking analysis lead us to h...

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Literature Corpus work: f8f9fec4-de6e-5878-84c1-61e909de5cc9
DOI: 10.2147/vaat.s12733

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